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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

JAMA · 23 February 2016

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Summary

An international task force's consensus update of the definitions of sepsis and septic shock, framing sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection. It also introduced qSOFA as a bedside prompt, and the definitions remain the standard reference in clinical practice and research.

Summary written by Sterling IMRES editors. Read the original abstract at the publisher.

Authors

  • Mervyn SingerBloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom
  • Clifford S. DeutschmanHofstra–Northwell School of Medicine, Feinstein Institute for Medical Research, New Hyde Park, New York
  • Christopher Warren SeymourDepartment of Critical Care and Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • Manu Shankar-HariDepartment of Critical Care Medicine, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
  • Djillali AnnaneDepartment of Critical Care Medicine, University of Versailles, France
  • Michael BauerCenter for Sepsis Control and Care, University Hospital, Jena, Germany
  • Rinaldo BellomoAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, and Austin Hospital, Melbourne, Victoria, Australia
  • Gordon R. BernardVanderbilt Institute for Clinical and Translational Research, Vanderbilt University, Nashville, Tennessee
  • Jean-Daniel ChicheRéanimation Médicale-Hôpital Cochin, Descartes University, Cochin Institute, Paris, France
  • Craig M. CoopersmithCritical Care Center, Emory University School of Medicine, Atlanta, Georgia

The full author list is available from the publisher.

Cite this work

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-810. doi:10.1001/jama.2016.0287

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