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In progressObservational

Dallas 2K: A Natural History Study of Depression

This is a registered study tracked in the Sterling IMRES research watch. It is sponsored by University of Texas Southwestern Medical Center and run by the investigators named in the registry, not by Sterling IMRES. Details come from ClinicalTrials.gov, last updated 15 September 2026.

Summary

Dallas 2K is a long-term observational cohort at UT Southwestern that follows people with elevated depressive symptoms. Participants contribute clinical, lifestyle, blood, genetic, neuroimaging and EEG data so researchers can look for markers linked to recovery. Follow-up is planned to continue into the 2030s.

Objectives

  • Identify and validate biological signatures that predict treatment response and outcomes in depression.
  • Follow changes in depression severity over time using questionnaires, blood biomarkers, genomics, brain imaging and EEG.

Methodology

Study design
Cohort observational study, prospective time perspective
Conditions
Depression; Depression, Bipolar
Interventions
Observational Study (other)
Primary outcome
Longitudinal changes in depression severity of subjects with elevated symptomatology on Patient Health Questionnaire (PHQ-9) for non-psychotic depressive disorders.
Sample size
2,500 participants (estimated)
Locations
United States

Team

0

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