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A Randomized Trial of Intensive versus Standard Blood-Pressure Control

New England Journal of Medicine · 26 November 2015

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Summary

Presents the main results of the SPRINT trial, which compared a systolic blood-pressure target below 120 mm Hg with a target below 140 mm Hg in adults at increased cardiovascular risk without diabetes. Its findings on cardiovascular events and mortality, weighed against higher rates of some adverse events, informed subsequent hypertension guidelines.

Summary written by Sterling IMRES editors. Read the original abstract at the publisher.

Authors

Group author: The SPRINT Research Group.

Cite this work

The SPRINT Research Group. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. New England Journal of Medicine. 2015;373(22):2103-2116. doi:10.1056/NEJMoa1511939

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SPRINT was a large US multicentre randomised trial run by the NHLBI that compared two blood pressure targets in adults with hypertension. Participants were assigned either to an intensive systolic target or to the conventional target, and were followed for major cardiovascular events. Its main findings were published in the New England Journal of Medicine in 2015.

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