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PublishedInterventional

Systolic Blood Pressure Intervention Trial

This is a registered study tracked in the Sterling IMRES research watch. It is sponsored by National Heart, Lung, and Blood Institute (NHLBI) and run by the investigators named in the registry, not by Sterling IMRES. Details come from ClinicalTrials.gov, last updated 8 January 2021.

Summary

SPRINT was a large US multicentre randomised trial run by the NHLBI that compared two blood pressure targets in adults with hypertension. Participants were assigned either to an intensive systolic target or to the conventional target, and were followed for major cardiovascular events. Its main findings were published in the New England Journal of Medicine in 2015.

Objectives

  • Test whether aiming for a systolic blood pressure below 120 mmHg, rather than below 140 mmHg, lowers the risk of heart attack, stroke, heart failure and cardiovascular death.
  • Compare the safety of intensive versus standard blood pressure treatment in adults at raised cardiovascular risk.

Methodology

Study design
Randomized, parallel assignment, single-blind, primary purpose: treatment
Conditions
Hypertension
Interventions
Intensive control of SBP (drug); Standard control of SBP (drug)
Primary outcome
Number of Participants With First Occurrence of a Myocardial Infarction (MI), Acute Coronary Syndrome (ACS), Stroke, Heart Failure (HF), or CVD Death
Sample size
9,361 participants (actual)
Locations
United States

Team

Findings and resulting publications

  • SPRINT Research Group; Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med. 2015 Nov 26;373(22):2103-16. doi: 10.1056/NEJMoa1511939. Epub 2015 Nov 9. PubMed 26551272

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2026