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PublishedInterventionalPhase 3

Diabetes and Periodontal Therapy Trial

A Multicenter Randomized Single-Masked Clinical Trial Testing the Effect of Non-surgical Periodontal Therapy on Glycosylated Hemoglobin (HbA1c) Levels in Subjects With Type 2 Diabetes and Chronic Periodontitis

This is a registered study tracked in the Sterling IMRES research watch. It is sponsored by Stony Brook University and run by the investigators named in the registry, not by Sterling IMRES. Details come from ClinicalTrials.gov, last updated 20 January 2014.

Summary

DPTT was a multicentre US randomised trial in adults with type 2 diabetes and moderate-to-advanced periodontitis. One group received scaling, root planing and supportive periodontal care straight away, while the other had treatment delayed. The primary result, published in JAMA in 2013, examined the effect on HbA1c.

Objectives

  • Test whether non-surgical periodontal therapy lowers HbA1c at six months in people with type 2 diabetes and chronic periodontitis.
  • Relate changes in gum health measures to changes in glucose control and insulin resistance.

Methodology

Study design
Randomized, parallel assignment, single-blind, primary purpose: treatment
Conditions
Chronic Periodontitis; Type 2 Diabetes
Interventions
Non-surgical periodontal therapy (procedure); Delayed non-surgical periodontal therapy (other)
Primary outcome
Change in Glycosylated Hemoglobin (HbA1c)
Sample size
514 participants (actual)
Locations
United States

Team

Findings and resulting publications

  • Engebretson SP, Hyman LG, Michalowicz BS, Schoenfeld ER, Gelato MC, Hou W, Seaquist ER, Reddy MS, Lewis CE, Oates TW, Tripathy D, Katancik JA, Orlander PR, Paquette DW, Hanson NQ, Tsai MY. The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial. JAMA. 2013 Dec 18;310(23):2523-32. doi: 10.1001/jama.2013.282431. PubMed 24346989

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