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UpcomingInterventionalPhase 2 / Phase 3

POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure

Point-of-care Ultrasound Intervention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure

This is a registered study tracked in the Sterling IMRES research watch. It is sponsored by Hospital de Clinicas de Porto Alegre and run by the investigators named in the registry, not by Sterling IMRES. Details come from ClinicalTrials.gov, last updated 18 March 2026.

Summary

This Brazilian randomised trial will test whether a point-of-care ultrasound congestion score can be used to adjust diuretic therapy for people admitted with acute decompensated heart failure. Patients in the ultrasound-guided arm may receive stepped combinations of diuretics such as furosemide, hydrochlorothiazide, acetazolamide and dapagliflozin based on their scans. Outcomes are compared using a hierarchical win-ratio approach.

Objectives

  • Find out whether bedside ultrasound assessment of congestion can guide diuretic treatment better than usual care in acute decompensated heart failure.
  • Compare a combined outcome of in-hospital death, length of stay, residual congestion and fall in BNP between the two strategies.

Methodology

Study design
Randomized, parallel assignment, single-blind, primary purpose: treatment
Conditions
Acute Heart Failure (AHF); Congestive Heart Failure Acute; Diuretic Effect; Lung Ultrasonography Score; Ultrasonography, Doppler; Point-of-care Ultrasound (POCUS)
Interventions
Furosemide 40 Milligrams. (drug); Furosemide 40 Milligrams. (drug); Hydrochlorothiazide (HCTZ) 25 milligrams. (drug); Acetazolamide 250 milligrams. (drug); Dapagliflozin (10mg Tab) (drug); Potassium Chloride Oral Product (drug)
Primary outcome
Pairwise Comparisons With Wins of Clinical Benefit, a Composite of In-Hospital Mortality, Hospital Length of Stay, Absence of Congestion on DUCS at Discharge, and BNP Reduction From Admission to Day 7 or Discharge.
Sample size
128 participants (estimated)
Locations
Brazil

Team

0

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